{"id":3764,"date":"2024-05-01T14:27:30","date_gmt":"2024-05-01T06:27:30","guid":{"rendered":"\/chemistry\/?p=3764"},"modified":"2024-09-13T10:07:30","modified_gmt":"2024-09-13T02:07:30","slug":"%e5%be%90%e7%a7%80%e7%a6%8f","status":"publish","type":"post","link":"\/chemistry\/?p=3764","title":{"rendered":"\u838a\u5b50\u8d85(\u671f\u520a)"},"content":{"rendered":"\n<div class=\"wp-block-tkuwpbs5-bs5-container container chem_teach\" style=\"margin-top:var(--wp--preset--spacing--40);padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50);position:relative\" block_id=\"lq3fs6oyzthhmnpj8a\"><style><\/style>\n<div class=\"wp-block-tkuwpbs5-bs5-row row\">\n<h4 class=\"wp-block-heading\"><strong>Selected Publications<\/strong><\/h4>\n\n\n\n<p><strong>M.-C. Kao*, G.-Y. Liu,&nbsp;<u>T.-C. Chuang<\/u>, Y.-S. Lin, J.-A. Wuu, S.-L. Law. The N-terminal 178-amino-acid domain only of the SV40 large T antigen acts as a transforming suppressor of the HER-2\/neu oncogene.&nbsp;<em>Oncogene.<\/em>&nbsp;1998; 16: 547-554.<\/strong><\/p>\n\n\n\n<p><strong>M.-C. Kao*, S.-L. Law,&nbsp;<u>T.-C. Chuang<\/u>&nbsp;and Y.-S. Lin. In virto gene transfer in mammalian cells via a new cationic liposome formulation.&nbsp;<em>Oncology reports<\/em>. 1998; 5: 625-629.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>S.-L. Law, M.-C. Kao,&nbsp;<u>T.-C. Chuang<\/u>. Formulation of transfection reagent of sphingosine and dioleoylphosphatidyl-ethanolamine.&nbsp;<em>ROC Patent<\/em>&nbsp;#114360, 2000.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong><u>T.-C. Chuang<\/u><\/strong><strong>, Y. Yu, Y.-S. Lin, S.-S. Wang, M.-C. Kao*. The N-terminal domain of SV40 Large T antigen represses the HER2\/neu-mediated transforming and metastatic potential in breast cancers.&nbsp;<em>FEBS Lett.<\/em>&nbsp;2002; 511: 46-50.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong><u>T.-C. Chuang<\/u><\/strong><strong>, T-D. Way, Y.-S. Lin, Y.-C. Lee, S.-L. Law, M.-C. Kao*. The Epstein-Barr virus nuclear antigen-1 may act as a transforming suppressor of the HER2\/neu oncogene.&nbsp;<em>FEBS Lett.<\/em>&nbsp;2002;532: 135-142.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong><u>T.-C. Chuang<\/u><\/strong><strong>, Y.-C. Lee, G.-Y. Liu, Y.-S. Lin, J.-Y. Li, V. Wang, S.-L. Law, M.-C. Kao*. EBNA1 may prolong G2\/M phase and sensitizes&nbsp;<em>HER2\/neu<\/em>-overexpressing ovarian cells to both topoisomerase II-targeting and paclitaxel drugs.&nbsp;<em>Biochem. Biophys. Res. Commun.<\/em>&nbsp;2003;307: 653-659.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>J.-W. Li,<u>&nbsp;T.-C. Chuang<\/u>, A.-H. Yang, C.-K. Hsu, M.-C. Kao*. Clinicopathological relevance of HER2\/neu and a related gene-protein cubic regression correlation in colorectal adenocarcinomas in Taiwan.&nbsp;<em>Int. J. Oncol.<\/em>&nbsp;2005;26: 933-944.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>V. Wang,<u>&nbsp;T.-C. Chuang<\/u>, Y.-D. Hsu, W.-Y. Chou, M.-C. Kao*.&nbsp;Nitric oxide induces prion protein via MEK and p38 MAPK signaling.&nbsp;<em>Biochem. Biophys. Res. Commun.<\/em>&nbsp;2005;333:&nbsp;95-100.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>S.-L. Law*,&nbsp;<u>T.-C. Chuang<\/u>, M.-C. Kao, Y.-S. Lin, K.-J. Huang. Gene transfer mediated by sphingosine\/ dioleoylphosphatidylethanolamine liposomes in the presence of poloxamer 188.&nbsp;<em>Drug Deliv.<\/em>&nbsp;2006;3: 61-67.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong><u>T.-C. Chuang*<\/u><\/strong><strong>, J.-Y. Liu, C.-T. Lin, Y.-T. Tang, M.-H. Yeh, S.-C. Chang, J.-W. Li, M.-C. Kao*. Human manganese superoxide dismutase suppresses HER2\/neu-mediated breast cancer malignancy.<em>&nbsp;FEBS Lett.<\/em>&nbsp;2007; 581: 4443-4449.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>C.-C. Ou, S.-C. Hsu, Y.-H. Hsieh, W.-L. Tsou,&nbsp;<u>T.-C. Chuang<\/u>, J.-Y. Liu*, M.-C. Kao*. Downregulation of HER2 by RIG1 involves the PI3K\/Akt pathway in ovarian cancer cells.&nbsp;<em>Carcinogenesis.<\/em>&nbsp;2008;29: 299-306.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>S.-C. Hsu, C.-C. Ou, J.-W. Li,&nbsp;<u>T.-C. Chuang*<\/u>, H.-P. Kuo, J.-Y, Liu, C.-S. Chen, S.-C. Lin, C.-H. Su, M.-C. Kao*. <\/strong><strong>Ganoderma tsugae extracts inhibit colorectal cancer cell growth via G(2)\/M cell cycle arrest.&nbsp;<em>J. Ethnopharmacol.<\/em>&nbsp;2008; 120: 394-401.&nbsp;<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>J.-Y. Liu,&nbsp;<u>T.-C. Chuang*<\/u>, T.-D. Way, T.-C. Tsai, C.-L. Hu, G.-Y. Liu, S.-S.-Wang, J.-G. Chung, M.-C. Kao*. The N-terminal domain of EBNA1 acts as a suppressor of the HER2\/neu oncogene.&nbsp;<em>Cancer Lett.<\/em>&nbsp;2009; 273: 273-280.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>V. Wang<sup>#<\/sup>,<u>&nbsp;T.-C. Chuang<sup>#<\/sup><\/u>, B.-W. Soong, D.-E. Shan*, M.-C. Kao*. Octarepeat changes of prion protein in Parkinson&#8217;s disease.&nbsp;<em>Parkinsonism Relat. Disord.<\/em>&nbsp;2009; 15: 53-58. (<sup>#<\/sup>co-first author)<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>S.-C. Hsu, C.-C. Ou,<u>&nbsp;T.-C. Chuang*<\/u>, J.-W. Li,&nbsp;Y.-J. Lee,&nbsp;V. Wang, J.-Y. Liu, C.-S. Chen, S.-C. Lin*, M.-C. Kao*.&nbsp;<\/strong>Ganoderma tsugae extract<strong>&nbsp;inhibits expression of epidermal growth factor receptor and angiogenesis in human epidermoid carcinoma cells:<em>&nbsp;in vitro<\/em>&nbsp;and&nbsp;<em>in vivo<\/em>.&nbsp;<em>Cancer Lett.<\/em>&nbsp;2009;&nbsp;281: 108-116.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>V. Wang*, S.-Y. Chen,&nbsp;<u>T.-C. Chuang<\/u>, D.-E Shan, B.-W. Soong, M.-C. Kao*. Val-9Ala and Ile+58Thr polymorphism of MnSOD in Parkinson\u2019s disease.&nbsp;<em>Clin. Biochem.<\/em>&nbsp;2010; 43: 979-982.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>H.-P. Kuo,&nbsp;<u>T.-C. Chuang<\/u>, M.-H. Yeh, S.-C. Hsu, T.-D. Way, P.-Y. Chen, S.-S. Wang, Y.-H. Chang, M.-C. Kao*, J.-Y. Liu*. Growth suppression of HER2-overexpressing breast cancer cells by berberine via modulating the HER2\/PI3K\/Akt signaling pathway.&nbsp;<em>J. Agric. Food Chem.<\/em>&nbsp;2011; 59: 8216-8224.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong><u>T.-C. Chuang*<\/u><\/strong><strong>, S.-C. Hsu, Y.-T. Cheng, W.-S. Shao, K. Wu, G.-S. Fang, C.-C. Ou, V. Wang. <\/strong><strong>Magnolol down-regulates HER2 gene expression, leading to inhibition of HER2-mediated metastatic potential in ovarian cancer cells.&nbsp;<em>Cancer Lett.<\/em>&nbsp;2011; 311: 11-19.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>V.-C. Wang*, J.-W. Li, J.-H. Suen,&nbsp;<u>T.-C. Chuang<\/u>, M.-C. Kao. Ile\/Ile homozygosity at codon 655 of HER2 in schwannoma.&nbsp;<em>Acta Neurol. Taiwan.<\/em>&nbsp;2011; 20: 243-248.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>H.-P. Kuo,&nbsp;<u>T.-C. Chuang<\/u>, S.-C. Tsai, H.-H. Tseng, S.-C. Hsu, Y.-C. Chen, C.-L. Kuo, Y.-H. Kuo, J.-Y. Liu, M.-C. Kao*. Berberine, an Isoquinoline Alkaloid, Inhibits the Metastatic Potential of Breast Cancer Cells via Akt Pathway Modulation.&nbsp;<em>J. Agric. Food Chem.<\/em>&nbsp;2012; 60: 9649-9658.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>V. Wang*,&nbsp;<u>T.-C. Chuang<\/u>, M.-C. Kao, D.-E Shan, B.-W. Soong, T.-M. Shieh. Polymorphic Ala-allele carriers at residue 1170 of HER2 associated with Parkinson&#8217;s disease.<em>&nbsp;J Neurol Sci.<\/em>&nbsp;2013; 325(1-2):115-9.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>H.-P. Kuo, S.-C. Hsu, C.-C. Ou, J.-W. Li, H.-H. Tseng,&nbsp;<u>T.-C. Chuang<\/u>, J.-Y. Liu, S.-J. Chen, M.-H. Su, Y.-C. Cheng, W.-Y. Chou, M.-C. Kao*. Ganoderma tsugae extract inhibits growth of HER2-overexpressing cancer cells via modulation of HER2\/PI3K\/Akt signaling pathway.<em>&nbsp;Evid Based Complement Alternat Med.<\/em>&nbsp;2013; 2013:219472.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong>H.-P. Kuo, Y.-J. Lee, C.-Y. Hsu, S.-L. Lee, S.-C. Hsu,&nbsp;<u>T.-C. Chuang<\/u>, J.-Y. Liu, C.-L. Kuo, C.-T. Ho, M.-C. Kao*.&nbsp;Growth-suppressive effect of berberine on endometrial carcinoma cells: Role of mitochondrial and PI3K\/Akt pathway.&nbsp;<em>J Funct Foods.<\/em>&nbsp;2015; 17: 600-609.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong><u>Chuang TC<\/u><\/strong><strong>*, Wu K, Lin YY, Kuo HP,&nbsp;Kao MC, Wang V, Hsu SC, Lee SL. Dual down-regulation of EGFR and ErbB2 by berberine contributes to suppression of migration and invasion of human ovarian cancer cells. Environ Toxicol. 2021; 36(5):737-747.<\/strong><strong><\/strong><\/p>\n\n\n\n<p><strong><u>Chuang TC*<\/u><\/strong><strong>, Shao WS, Hsu SC, Lee SL, Kao MC, Wang V.&nbsp;Baicalein Induces G2\/M Cell Cycle Arrest Associated with ROS Generation and CHK2 Activation in Highly Invasive Human Ovarian Cancer Cells.&nbsp;<em>Molecules<\/em>&nbsp;2023; 28: 1039.<\/strong><\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":17,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"wp-custom-template-member-empty-template","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"acf":[],"_links":{"self":[{"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/posts\/3764"}],"collection":[{"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/users\/17"}],"replies":[{"embeddable":true,"href":"\/chemistry\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3764"}],"version-history":[{"count":4,"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/posts\/3764\/revisions"}],"predecessor-version":[{"id":5735,"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/posts\/3764\/revisions\/5735"}],"wp:attachment":[{"href":"\/chemistry\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3764"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/chemistry\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3764"},{"taxonomy":"post_tag","embeddable":true,"href":"\/chemistry\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3764"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}