{"id":3769,"date":"2024-11-19T11:02:27","date_gmt":"2024-11-19T03:02:27","guid":{"rendered":"\/chemistry\/?p=3769"},"modified":"2026-06-01T13:49:19","modified_gmt":"2026-06-01T05:49:19","slug":"%e6%96%bd%e5%a2%9e%e5%bb%89","status":"publish","type":"post","link":"\/chemistry\/?p=3769","title":{"rendered":"\u65bd\u589e\u5ec9(\u671f\u520a)"},"content":{"rendered":"\n<div class=\"wp-block-tkuwpbs5-bs5-container container chem_teach\" style=\"margin-top:var(--wp--preset--spacing--40);padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50);position:relative\" block_id=\"lq3fs6oyzthhmnpj8a\"><style><\/style>\n<div class=\"wp-block-tkuwpbs5-bs5-row row\">\n<h4 class=\"wp-block-heading\"><strong>\u5c08\u66f8&nbsp;(Books)<\/strong><\/h4>\n\n\n\n<p>1. \u6709\u6a5f\u5316\u5b78\u7cbe\u83ef&nbsp;(Essential Organic Chemistry; 3rd ed; Paula Yurkanis Bruice).&nbsp;<strong>2019<\/strong>.<strong>07<\/strong> \u65bd\u589e\u5ec9&nbsp;\u7de8\u8b6f &nbsp;<\/p>\n\n\n\n<p>2. \u7406\u89e3\u6709\u6a5f\u5316\u5b78 \u65bd\u589e\u5ec9\u7de8\u8457&nbsp;<strong>2023.10<\/strong><\/p>\n\n\n\n<p>3. \u6709\u6a5f\u5316\u5b78  \u57fa\u790e\u8207\u9032\u968e \u65bd\u589e\u5ec9\u7de8\u8457 <strong>2025<\/strong>.<strong>7<\/strong><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-tkuwpbs5-bs5-row row\">\n<h4 class=\"wp-block-heading\"><strong>\u5c08\u5229(Patents)<\/strong><\/h4>\n\n\n\n<p>1.\u6740\u83cc\u5242\u53ca\u6740\u83cc\u65b9\u6cd5 \u53d1\u660e\u4eba\uff1a\u80e1\u5b89\u4ec1;\u65bd\u589e\u5ec9;\u6d2a\u5d27\u58ec;\u9648\u704f\u5e73 \u4e2d\u83ef\u4eba\u6c11\u5171\u548c\u570b \u8bc1\u4e66\u53f7\u7b2c7178191\u53f7<\/p>\n\n\n\n<p>2. \u6bba\u83cc\u5291\u53ca\u5176\u7528\u9014 \u80e1\u5b89\u4ec1 \u65bd\u589e\u5ec9 \u6d2a\u5d27\u58ec \u9673\u705d\u5e73&nbsp;\u4e2d\u83ef\u6c11\u570b\u767c\u660e\u5c08\u5229\u7b2c&nbsp;I748646&nbsp;\u865f<\/p>\n\n\n\n<p>3. \u5df1\u4e8c\u70ef\uff0d3,4\u4e8c\u916e\u985e\u6216\u55b9\u35c1\u5549\u985e\u5316\u5408\u7269\u6216\u5176\u91ab\u85e5\u5b78\u4e0a\u53ef\u63a5\u53d7\u4e4b\u9e7d\u7528\u65bc\u88fd\u5099\u6291\u5236\u80f0\u81df\u764c\u4e4b\u85e5\u7269\u7684\u7528\u9014&nbsp;&nbsp;\u65bd\u589e\u5ec9\u3001\u9673\u65e5\u69ae\u3001\u738b\u777f\u745c\u3001\u5353\u66f8\u6fa4\u3001\u5f35\u5cfb\u8c6a&nbsp;\u4e2d\u83ef\u6c11\u570b\u767c\u660e\u5c08\u5229\u7b2c&nbsp;I776736&nbsp;\u865f<\/p>\n\n\n\n<p>4. \u542b\u7852\u5143\u7d20\u7684\u67e5\u723e\u916e\u5316\u5408\u7269\u53ca\u5176\u88fd\u5099\u65b9\u6cd5\u3001\u5305\u542b\u5176\u7684\u91ab\u85e5\u7d44\u5408\u7269\u3001\u4ee5\u53ca\u7528\u65bc\u88fd\u5099\u9810\u9632\u6216\u6cbb\u7642\u5927\u8178\u764c\u4e4b\u91ab\u85e5\u7d44\u5408\u7269\u7684&nbsp; \u7528\u9014&nbsp;&nbsp;\u65bd\u589e\u5ec9\u3001\u9673\u65e5\u69ae\u3001\u9673\u4e9e\u8fb0\u3001\u674e\u91c7\u8473&nbsp;\u4e2d\u83ef\u6c11\u570b\u767c\u660e\u5c08\u5229\u7b2cI811116<\/p>\n\n\n\n<p>5\u7852\u5429\u57fa\u8272\u539f\u916e\u884d\u751f\u7269\u53ca\u5176\u7528\u9014 \u65bd\u589e\u5ec9 \u5f35\u50b3\u99a8 \u9673\u4e9e\u8fb0 \u6e6f\u7f8e\u99a8 \u4e2d\u83ef\u6c11\u570b\u767c\u660e\u5c08\u5229\u7b2cI873001\u865f<\/p>\n\n\n\n<p>6.\u7852\u5429\u57fa\u67e5\u723e\u916e\u884d\u751f\u7269\u53ca\u5176\u7528\u9014  \u65bd\u589e\u5ec9 \u5f35\u50b3\u99a8 \u9673\u4e9e\u8fb0  \u4e2d\u83ef\u6c11\u570b\u767c\u660e\u5c08\u5229\u7b2cI896052\u865f<\/p>\n\n\n\n<p>7. \u78b2-\u7570\u5432\u54da\u5549\u5316\u5408\u7269\u7528\u65bc\u88fd\u5099\u6cbb\u7642\u80ba\u764c\u548c\u982d\u9838\u764c\u4e4b\u91ab\u85e5\u7d44\u5408\u7269\u53ca\u5176\u7528\u9014 \u65bd\u589e\u5ec9\u3001\u5f35\u50b3\u99a8\u3001\u8a31\u535a\u667a\u3001\u8521\u5ead\u5b87\u3001\u76db\u7d2b\u7b60 \u4e2d\u83ef\u6c11\u570b\u767c\u660e\u5c08\u5229\u7b2cI926697\u865f<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-tkuwpbs5-bs5-row row\">\n<h4 class=\"wp-block-heading\"><strong>\u671f\u520a\u8ad6\u6587<\/strong><\/h4>\n\n\n\n<p>1. Hsu, P.-C.;  Chien, C.-C<strong>.;<\/strong> Cheng, Y.-J.;  <strong>Chang*, C-H<\/strong>.;  <strong>Shih*, T.-L.<\/strong><a> <\/a>&#8220;Flavones and aminoflavones increase the cytotoxicity of NK cells in human non-small cell lung cancer&#8221; <em>J. Cell. Mol. Med. <\/em><strong>2026<\/strong>, <em>30<\/em>, e71055.<\/p>\n\n\n\n<p>2. <a>Hu, A.;  Lin, S. Y.;  <strong>Cheng*, S-C.<\/strong>;  <\/a><strong><a>Shih<\/a>*, T.-L<\/strong>. &#8220;<a>Determine of pH-Dependent Diketo and Keto-Enol Tautomers of Curcumin Analogs by Ultraperformance Liquid Chromatography-Mass Spectrometry<\/a>&#8221; <em>MicroChem. J.<\/em> <strong> 2026<\/strong>, <em>220<\/em>, 116375. <\/p>\n\n\n\n<p>3. Hung, S.-J.; Chiang, L.-Y.;  Hong, Y.-A.;  Chang, K.-C.;  Cheng, Y.-J.;  Wu, H.-Y.;  Hu, A.;   Hamid, H.; <strong>Shih*, T.-L<\/strong>.;   <strong>Chen*, H.-P.<\/strong> &#8220;Photodynamic agents of synthetic curcuminoids with antibacterial and anticancer activities&#8221; <em>Organics<\/em>, <strong>2026<\/strong>, <em>7<\/em>, 1.<\/p>\n\n\n\n<p>4.  Lu, W.-J.; Li, J.-Y.; <strong>Shih, T.-L.<\/strong>; Chen, R.-J.; Chen, T.-Y.; Kao, W.-T.; Liue, J.-W.; Wang, H.-H.; Peng, H.-Y.; Lin, K. H. \u201cA naphthalimide derivative exerts potent antiplatelet and antithrombotic activities without a bleeding tendency\u201d<em> Front. Pharmacol.<\/em><strong> 2025<\/strong>, <em>16<\/em>, 1541255. <\/p>\n\n\n\n<p>5. Hsu, P.-C.; Hsu, Y.-H.; <strong>Chang*, C.-H.<\/strong>; <strong>Shih*, T.-L.<\/strong> \u201cDesign and synthesis of unsymmetric benzils, quinoxalines, and evaluations of their anticancer activities against human non-small lung cancer cells\u201d <em>ChemMedChem<\/em> <strong>2025<\/strong>, <em>20<\/em>, e202400847.<\/p>\n\n\n\n<p>6. Lee, C. C.; Chang, C.-H.; <strong>Huang*, Y.-C<\/strong>.; <strong>Shih*, T.-L<\/strong>. \u201cNovel 1,8-Naphthalimide Derivatives Inhibit Growth and Induce Apoptosis in Human Glioblastoma\u201d <em>Int. J. Mol. Sci.<\/em> <strong>2024<\/strong>,<em> 25<\/em>, 11593<\/p>\n\n\n\n<p>7. Hong, Y.-A.; Khine, A. A.; Lin, Y.-W.; Lee, P.-Y.; Hong, W.-X.; Hu, A.; <strong>Shih*, T.-L.<\/strong>; <strong>Chen*, H.-P.<\/strong>  \u201cMetabolic engineering of the borneol and camphor degradation pathways in Pseudomonas to produce optically pure bicyclic monoterpenes\u201d <em>Enzyme Microb. Technol.<\/em> <strong>2024<\/strong>, <em>181<\/em>, 110527.<\/p>\n\n\n\n<p>8. Wu, T.-W.; Chu, Y.-C.; Chang, C.-H; Hsieh, Y.-H.; Tang, M.-H.; Hsu, P.-H.; Wu, H.-Y.; <strong>Chen*, J.-J<\/strong>, <strong>Shih*, T.-L.<\/strong> \u201cFlavonol-ruthenium complexes as antioxidant and anticancer agents\u201d <em>ChemMedChem<\/em>.<strong> 2024<\/strong>,<em> 19<\/em>, e202400313.<\/p>\n\n\n\n<p>9. Liang, J.-H.; Cho, S.-T.; <strong>Shih*, T.-L.<\/strong>; <strong>Chen*, J.-J.<\/strong> \u201cSynthesis of quinoxalines and assessment of their inhibitory effects against human non-small-cell lung cancer cells\u201d <em>RSC. Adv.<\/em><strong> <\/strong><strong>2024<\/strong>, <em>14<\/em>, 28659-28668.<\/p>\n\n\n\n<p>10. Cheng, Y.-J.; Lin, J.-Y.; <strong>Shih*, T.-L.<\/strong>; <strong>Hsieh*, C-H.<\/strong> \u201cSingle-Crystal X-ray Analysis of the Diketo form of Asymmetric Curcuminoids and Coupled with NMR Insights into Its <em>\u03b2<\/em>-Keto-enol Tautomerization at Ambient Temperature\u201d<em> J. Chin. Chem. Soc.<\/em> <strong>2024<\/strong>, <em>71<\/em>, 1396-1401.<\/p>\n\n\n\n<p>11. Chen, Y.-C.; Chang, C.-H.; Tang, M.-H.; Ding, Y. C.; Wu, I.-C.; Ye, W.-T.; <strong>Shih*, T.-L.<\/strong> \u201cSynthesis of selenophene-containing flavonols and 2-styrylchromones. Evaluations of their activities compared with selenophene-containing chalcones as potential anticancer agents\u201d <em>Arch. Pharm.<\/em> <strong>2024<\/strong>,<em> 357<\/em>, e2400242.<\/p>\n\n\n\n<p>12. Hsieh, Y.-H.; Hsu, P.-H.; Hu, A.; Cheng, Y.-J.; <strong>Shih*, T.-L<\/strong>.; <strong>Chen*, J.-J<\/strong>. \u201cSynthesis of Flavonols and Assessment of Their Biological Activity as Anticancer Agents\u201d <em>Molecules<\/em> <strong>2024<\/strong>, <em>29<\/em>, 2041<\/p>\n\n\n\n<p>13. Ding, Y. C.; Chu, Y.-C.; Chang, C.-H.; Liang, J.-H.; <strong>Chen*, J.-J.<\/strong>; <strong>Shih*, T.-L<\/strong>. \u201cSynthesis of 2\u2010(pyridylvinyl)chromen\u20104\u2010ones and their <em>N<\/em>\u2010oxide analogs for assessment of their biological activities as anticancer agents\u201d<em> Arch. Pharm.<\/em> <strong>2024<\/strong>, <em>357<\/em>, e202300445<\/p>\n\n\n\n<p>14. Chen, Y.-X; Chang, C.-H.; Li, C.-W.;&nbsp;<strong>Chen*, J.-J<\/strong>.; <strong>Shih*, T.-L<\/strong>.&#8221;Design, synthesis and evaluation of 1,2,3-triazole-based benzenesulfonamide and flavonol hybrid molecules as anticancer agents&#8221;&nbsp;<em>J. Chin. Chem. Soc<\/em>.&nbsp;<strong>2023,&nbsp;<\/strong><em>70<\/em>, 1924-1936 (<strong>cover feature, Highly cited paper award 2024<\/strong>)<\/p>\n\n\n\n<p>15. Chen, Y.-C.;&nbsp;&nbsp;Chu Y.-C.; Li, C.W.;&nbsp;&nbsp;<strong>Chen*, J.-J.<\/strong>;&nbsp;<strong>Shih*, T.-L<\/strong>.&nbsp;&#8220;Synthesis and evaluation of 6-amino-2-styrylchromones as anticancer agents&#8221;&nbsp;<em>ChemistrySelect<\/em>&nbsp;<strong>2023<\/strong>,&nbsp;<em>8<\/em>,&nbsp;e202300685<\/p>\n\n\n\n<p>16. Chen, Y.-C.; Li, C.-W.;&nbsp;<strong>Chen*, J.-J.<\/strong>;&nbsp;<strong>Shih*, T.-L.<\/strong>&nbsp;\u201cSynthesis of selenophene-based chalcone analogues and assessment of their biological activity as anti-cancer agents\u201d<em>&nbsp;Arch. Pharm.<\/em>&nbsp;<strong>2023,<\/strong><em>&nbsp;356<\/em><strong>,&nbsp;<\/strong>e2200486<strong>.<\/strong><\/p>\n\n\n\n<p>17. Cheng, Y.-J.; Li, C.-W.; Kuo, C.-L.;&nbsp;<strong>Shih*,<\/strong><strong>&nbsp;T.-L.<\/strong>;&nbsp;<strong>Chen*, J.-J.<\/strong>&nbsp;\u201cImproved Synthesis of Asymmetric Curcuminoids and Their Assessment as  Antioxidants\u201d<em>&nbsp;Molecules<\/em>&nbsp;<strong>2022<\/strong>,&nbsp;<em>27<\/em>, 2547.<\/p>\n\n\n\n<p>18. Wang, R.-Y.; Li, C.-W.; Cho, S.-T.; Chang, C-H.;&nbsp;<strong>Chen*,<\/strong><strong>&nbsp;J.-J.<\/strong>;&nbsp;<strong>Shih*, T.-L.<\/strong>&nbsp;\u201cSynthesis of cinnamils and quinoxalines and their biological evaluation as anti-cancer agents\u201d&nbsp;<em>Arch. Pharm.<\/em><strong>&nbsp;2022,&nbsp;<\/strong><em>355<\/em>, 2100448.<\/p>\n\n\n\n<p>19. <strong>Shih<\/strong>,&nbsp;<strong>T.-L<\/strong>.; Lin, K.-H.; Chen, R.-J.; Chen, T.-Y.; Kao, W.-T.; Liu, J.-W.; Wang, H.-H.; Peng, H.-Y.; Sun, Y.-Y.; Lu, W.-J.* \u201cA novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI\u201d&nbsp;<em>J. Cell. Mol. Med.<\/em>&nbsp;<strong>2021,<\/strong><strong>&nbsp;<\/strong><em>25<\/em><strong>,&nbsp;<\/strong>9434-9446<strong>.<\/strong><\/p>\n\n\n\n<p>20. Tsai, H. Y.; Huang, Y.-T.; Kuo, C.-L.; Kuo, C.-J.;&nbsp;<strong>Hu*,<\/strong><strong>&nbsp;A<\/strong>.;&nbsp;<strong>Chen*,<\/strong><strong>&nbsp;J.-J<\/strong>.;&nbsp;<strong>Shih*, T.-L<\/strong>. \u201cA case study of the iodine-mediated cyclization of C2\u2019-OH- and C2-OH-chalcones toward the synthesis of flavones. Reinvestigation of the mechanisms\u201d&nbsp;<em>J. Chin. Chem. Soc.&nbsp;<\/em><strong>2021<\/strong>,&nbsp;<em>68<\/em>, 1334-1338.<\/p>\n\n\n\n<p>21. Hung, S.-J.; Hong, Y.-A.; Lin, K.-Y.; Hua, Y.-W.; Kuo, C.-J.;&nbsp;<strong>Hu*, A<\/strong>.;&nbsp;<strong>Shih*,&nbsp;T.-L<\/strong>.;&nbsp;<strong>Chen*,&nbsp;H.-P.<\/strong>&nbsp;\u201cEfficient Photodynamic Killing of Gram-Positive Bacteria by Synthetic Curcuminoids\u201d&nbsp;<em>Int. J. Mol. Sci.<\/em>&nbsp;<strong>2020<\/strong>,&nbsp;<em>21<\/em>, 9024.<\/p>\n\n\n\n<p>22. Tung, C.-H.; Lu, Y.-T.; Kao, W.-T.; Liu, J.-W.; Lai, Y.-H.; Jiang, S.-J.;&nbsp;<strong>Chen*, H.-P.<\/strong>;&nbsp;<strong>Shih*, T.-L<\/strong>. \u201cDiscovery of a more potent anti-cancer agent than C4-benzazole 1,8-naphthalimide derivatives against murine melanoma\u201d&nbsp;<em>J. Chin. Chem. Soc.&nbsp;<\/em><strong>2020<\/strong>,&nbsp;<em>67<\/em>, 1254-1262. (Cover figure).<\/p>\n\n\n\n<p>23. Wang, R.-Y.; Kao, W.-T.;<strong>&nbsp;Shih*, T.-L.<\/strong>&nbsp;\u201cSynthesis of selenium-containing biindolyls and their Diels-Alder reaction toward the synthesis of hetero-annulated[a]- and [c]-carbazoles\u201d&nbsp;<em>J. Chin. Chem. Soc.<\/em>&nbsp;<strong>2020<\/strong>,&nbsp;<em>67<\/em>, 829-837.<\/p>\n\n\n\n<p>24. Tsai, M.-C.; Huang, P. Y.; Syu, L. S.;<strong>&nbsp;Shih*, T.-L<\/strong>. \u201cSynthesis of novel isoquinolino[5,4-ab]phenanthridine derivatives via Pictet-Spengler reaction\u201d<em>&nbsp;Synthesis<\/em>&nbsp;<strong>2019<\/strong>,<em>&nbsp;51<\/em>, 1377-1382.<\/p>\n\n\n\n<p>25. Yang, M.-Y.; Khine, A. A.; Liu, J.-W.; Cheng, H.-C.;&nbsp;<strong>Hu*, A<\/strong>.;&nbsp;<strong>Chen*, H.-P.<\/strong>;<strong>&nbsp;Shih*, T.-L.<\/strong>&nbsp;&#8220;Resolution of Isoborneol and its Isomers by GC\/MS to Identify \u201cSynthetic\u201d and \u201cSemi-synthetic\u201d Borneol Products.&#8221;&nbsp;<em>Chirality<\/em>&nbsp;<strong>2018<\/strong>,&nbsp;<em>30<\/em>, 1233-1239.<\/p>\n\n\n\n<p>26. <strong>Shih, T.-L.<\/strong>; Liu, M.-H.; Li, C.-W.;&nbsp;<strong>Kuo*, C.-F<\/strong>. \u201cHalo-Substituted Chalcones and Azachalcones-Inhibited, Lipopolysaccharited-Stimulated, Pro-Inflammatory Responses through the TLR4-Mediated Pathway\u201d&nbsp;<em>Molecules<\/em>&nbsp;<strong>2018<\/strong>,&nbsp;<em>23<\/em>, 597.<\/p>\n\n\n\n<p>27. Ho, T.-J.; Hung, C.-C.;&nbsp;<strong>Shih, T.-L<\/strong>.; Yiin, L.-M.; Chen, H.-P \u201cInvestigation of borneols sold in Taiwan by chiral gas chromatography\u201d<em>&nbsp;J. Food. Drug. Anal.<\/em>&nbsp;<strong>2018<\/strong>,&nbsp;<em>26<\/em>, 348-352.<\/p>\n\n\n\n<p>28. Li, C.-W.; Shen, T.-H;<strong>&nbsp;Shih*, T.-L<\/strong>. \u201cReinvestigation of synthesis of halo-substituted 3-phenyl-1-(2-pyridyl)-2-propen-1-ones (azachalcones). A tandem reaction for formation of penta-substituted cyclohexanols\u201d&nbsp;<em>Tetrahedron<\/em>&nbsp;<strong>2017<\/strong>,&nbsp;<em>73<\/em>, 4644-4652.<\/p>\n\n\n\n<p>29. Lu, Y.-T.; Chen, T.-L.; Chang, K.-S.; Chang, C.-M.; Wei, T.-Y.; Liu, J.-W.; Hsiao, C.-A.;<strong>&nbsp;Shih*, T.-L.<\/strong>&nbsp;\u201cSynthesis of novel C4-benzazole naphthalimide derivatives with potentanti-tumor properties against murine melanoma\u201d<em>&nbsp;Bioorg. Med. Chem.<\/em>&nbsp;<strong>2017<\/strong>,&nbsp;<em>25<\/em>, 789-794.<\/p>\n\n\n\n<p>30. Chen, Y.-R.; Cho, Y. C.;&nbsp;<strong>Shih*, T.-L.<\/strong>&nbsp;\u201cReinvestigation of ortho-amidoacetophenones\u2019 cyclization mediated by trimethylsilyl trifluoromethanesulfonate. The Lewis-acid-assisted and Br\u00f8nsted-acid-catalyzed reaction\u201d<em>&nbsp;Tetrahedron&nbsp;<\/em><strong>2016<\/strong>,&nbsp;<em>72<\/em>, 2006-2011.<\/p>\n\n\n\n<p>31. <strong>Shih*, T.-L<\/strong>.; Liao, W.-Y.; Yen, W.-C. \u201cRegioselective fluorination in synthesis of deoxyfluoro quercitols from&nbsp;D-(-)-quinic acid\u201d&nbsp;<em>Tetrahedron<\/em>&nbsp;<strong>2014<\/strong>,&nbsp;<em>70<\/em>, 9621-9627.<\/p>\n\n\n\n<p>32. <strong>Shih*, T.-L<\/strong>.; Chou, C.-E.; Liao, W.-Y.; Hsiao, C.-A. \u201cCopper-mediated trimethylsilyl azide in amination of bromoflavonoids to synthesize unique aminoflavonoids\u201d&nbsp;<em>Tetrahedron<\/em>&nbsp;<strong>2014<\/strong>,&nbsp;<em>70<\/em>, 3657-3664.<\/p>\n\n\n\n<p>33. Tai, C.-K.; Yeh, P.-L.; Wu, Y.-S.;&nbsp;<strong>Shih*, T.-L<\/strong>.; <strong>Wang*, B.-C<\/strong>. \u201cTheoretical investigation of conformational stabilities and&nbsp;<sup>13<\/sup>C NMR chemical shifts of a seven-membered ring thiosugar, (3<em>R<\/em>,4<em>R<\/em>,5<em>R<\/em>,7<em>S<\/em>)-7-(hydroxymethyl)thiepane-3,4,5-triol\u201d&nbsp;<em>J. Mol. Stru.<\/em><strong>&nbsp;2014<\/strong>,&nbsp;<em>1068<\/em>, 84-93.<\/p>\n\n\n\n<p>34. <strong>Shih*, T.-L<\/strong>.; Gao, W.-L. \u201cThe First Synthesis of 7-(Hydroxymethyl)thiepane-3,4,5-triols from&nbsp;D-(-)-Quinic Acid\u201d&nbsp;<em>Tetrahedron&nbsp;<\/em><strong>2013<\/strong>,&nbsp;<em>69<\/em>, 1897-1903.<\/p>\n\n\n\n<p>35.&nbsp;Chen, H.-H.; Lin, H.-A.; Lai, Y.-H.; Lin, S.-Y.; Chiang, C.-H.; <strong>Hsu*, H.-F<\/strong>.;&nbsp;<strong>Shih*, T.-L<\/strong>.; Lee, J.-J.; Lai, C.-C.; Kuo, T.-S.; \u201cEnantiotropic Nematics From Cross-Like 1,2,4,5-Tetrakis(4-Alkyl-4-Ethynylbiphenyl)Benzenes And Their Biaxiality Studies\u201d&nbsp;<em>Chem. Eur. J.<\/em>&nbsp;<strong>2012<\/strong>,&nbsp;<em>18<\/em>, 9543-9551.<\/p>\n\n\n\n<p>36. <strong>Shih*, T.-L<\/strong>.; Hsiao, C.-A.; Lin, Z.-Y.; <strong>Chen*, Y.-H<\/strong>. \u201cAn Alternative Synthesis of 3\u2019,4\u2019-Diaminoflavones to Evaluate Their Antioxidant Ability and Cell Apoptosis of Zebrafish Larvae\u201d&nbsp;<em>Molecules<\/em>&nbsp;<strong>2012<\/strong>,&nbsp;<em>17<\/em>, 8206-8216.<\/p>\n\n\n\n<p>37. Chen, H.-H.; Lin, H.-A.; Chien, S.-C.; Wang, T.-H.; <strong>Hsu*, H.-F<\/strong>.;&nbsp;<strong>Shih*, T.-L<\/strong>.; Wu, C. \u201cSingle-component room-temperature discotic nematic liquid crystals formed by introducing an attraction-enhancing inplane protrusion onto the hexa(phenylethynyl)benzene core\u201d&nbsp;<em>J. Mater. Chem.<\/em>&nbsp;<strong>2012<\/strong>,&nbsp;<em>22<\/em>, 12718-12722.<\/p>\n\n\n\n<p>38. Yeh, P.-L.; Tai, C.-K.;&nbsp;<strong>Shih*, T.-L.<\/strong>; Hsiao, H.-L.; <strong>Wang*, B.-C<\/strong>. \u201cConformational analysis of a seven-membered ring azasugar, (3<em>R<\/em>,4<em>R<\/em>,6<em>S<\/em>)-trihydroxyazepane: Comparison of GIAO calculation andexperimental NMR spectra on <sup>13<\/sup>C chemical shifts\u201c&nbsp;<em>J. Mol. Stru<\/em>.<strong>&nbsp;2012<\/strong>,&nbsp;<em>1018<\/em>, 64-71.<\/p>\n\n\n\n<p>39. <strong>Shih*, T.-L<\/strong>.; Yang, S.-Y. \u201cRegioselectivity in the Ring Opening of Epoxide for the Synthesis of Aminocyclitols from&nbsp;D-(-)-Quinic Acid\u201d&nbsp;<em>Molecules<\/em>&nbsp;<strong>2012<\/strong>,<em>&nbsp;17<\/em>, 4498-4507.<\/p>\n\n\n\n<p>40. Chen*, Y.-H.; Yang, Z.-S.; Wen, C.-C.; Chang, Y.-S.; <strong>Wang*, B.-C<\/strong>.; Hsiao, C.-A.;&nbsp;<strong>Shih*, T.-L<\/strong>. \u201cEvaluation of the structure-activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae\u201d<em>&nbsp;Food<\/em>&nbsp;<em>Chemistry.<\/em>&nbsp;<strong>2012<\/strong>,&nbsp;<em>134<\/em>, 717-724.<\/p>\n\n\n\n<p>41. <strong>Shih*, T.-L.<\/strong>; Liang, M.-C.; Wu, K.-D.; <strong>Lin*, C.-H<\/strong> \u201cSynthesis of Polyhydroxy 7- and&nbsp;<em>N<\/em>-Alkyl-Azepanes as potent Glycosidase Inhibitors\u201d&nbsp;<em>Carbohydr. Res.<\/em>&nbsp;<strong>2011<\/strong>,&nbsp;<em>346<\/em>, 183-190.<\/p>\n\n\n\n<p>42. S<strong>hih*, T.-L<\/strong>.; Li, H.-Y.; Ke, M.-S.; Kuo, W.-S. \u201cSynthesis of a New Family of Aminocyclitols from&nbsp;D-(-)- Quinic Acid\u201d&nbsp;<em>Synth. Commun<\/em>.&nbsp;<strong>2008<\/strong>,&nbsp;<em>38<\/em>, 4139-4149.<\/p>\n\n\n\n<p>43. <strong>Shih*, T.-L<\/strong>.; Yang, R.-Y.; Li, S.-T.; Chiang, C.-F.; <strong>Lin*, C.-H<\/strong>. &#8221;Expeditious Synthesis of Tri- and Tetrahydroxyazepanes from&nbsp;D-(-)-Quinic Acid as Potent Glycosidase Inhibitors &#8221;&nbsp;<em>J. Org. Chem<\/em>.&nbsp;<strong>2007<\/strong>,&nbsp;<em>72<\/em>, 4258-4261.<\/p>\n\n\n\n<p>44. <strong>Shih*, T.-L.<\/strong>; Fang, Y.-J. &#8221;An expeditious synthesis of new 3,4,6-trihydroxythiepanes from&nbsp;D-(-)-quinic acid&#8221;<em>&nbsp;Synth. Commun.<\/em>&nbsp;<strong>2007<\/strong>,<em>&nbsp;37<\/em>, 3337-3349.<\/p>\n\n\n\n<p>45. <strong>Shih*, T.-L<\/strong>.; Lin, Y.-L. &#8221;Epoxidation of protected 1,4,5-cyclohex-2-ene-triols and their acid hydrolysis to synthesize quercitols from&nbsp;D-(-)-quinic acid&#8221;&nbsp;<em>Synth. Commun<\/em>.&nbsp;<strong>2005<\/strong>,&nbsp;<em>35<\/em>, 1809-1817.<\/p>\n\n\n\n<p>46. <strong>Shih*, T.-L<\/strong>.; Lin, Y. -L.; Kuo, W. -S. &#8220;Highly stereoselective and stereospecific syntheses of a variety of quercitols from&nbsp;D-(-)-quinic acid&#8221;&nbsp;<em>Tetrahedron<\/em>&nbsp;<strong>2005<\/strong>,&nbsp;<em>61<\/em>, 1919-1924.<\/p>\n\n\n\n<p>47. <strong>Shih*, T.-L<\/strong>.; Kuo, W.-S.; Lin, Y.-L. &#8220;A facile synthesis of a new trihydorxy piperidine derivative and (+)-proto-quercitol from&nbsp;D-(-)-quinic acid&#8221;&nbsp;<em>Tetrahedron Lett.<\/em>&nbsp;<strong>2004<\/strong>,&nbsp;<em>45<\/em>, 5751-5754.<\/p>\n\n\n\n<p>48. <strong>Shih*, T.-L<\/strong>.; Tseng, J.-H. &#8220;An efficient synthesis of&nbsp;L-allono-1,4-lactone from 2,3;5,6-di-<em>o<\/em>-isopropylidene-D-mannono-1,4-lactone&#8221;&nbsp;<em>Tetrahedron Lett.<\/em>&nbsp;<strong>2004<\/strong>,&nbsp;<em>45<\/em>, 1789-1791.<\/p>\n\n\n\n<p>49. Paquette, L.A.; Zeng, Q.; Wang, H.-L.;&nbsp;<strong>Shih, T.-L.<\/strong>\u201cFrom Carbohydrates to the Discovery of Pronounced Heteroatomic Effects on Anionically Accelerated [3,3]-Sigmatropic Rearrangements\u201d&nbsp;<em>Eur. J. Org. Chem.&nbsp;<\/em><strong>2000<\/strong>, 2187.<\/p>\n\n\n\n<p>50. <strong>Shih*, T.-L<\/strong>.;&nbsp;<strong>Wu*, S.-H.<\/strong>\u201c Efficient Syntheses of (-)-Shikimate and (-)-Quinate 3-Phosphated via Trans Vicinal Diol Protection with 2,2,3,3-Tetramethoxy Butane\uff08TMB\uff09of Shikimic and Quinic Acid \u201d&nbsp;<em>Tetrahedron Lett.<\/em><strong>&nbsp;2000<\/strong>,<em>&nbsp;41<\/em>, 2957.<\/p>\n\n\n\n<p>51. <strong>Shih*, T.-L<\/strong>.; Chen, M.-C.;&nbsp;<strong>Wu*, S.-H.<\/strong>&nbsp;\u201cChemoenzymatic Preparation of 4-<em>O<\/em>-Acetyl Sialic Acid Derivative\u201d<em>&nbsp;Tetrahedron Lett.<\/em>&nbsp;<strong>2000<\/strong>,&nbsp;<em>41<\/em>, 7921.<\/p>\n\n\n\n<p>52. Paquette, L. A.;&nbsp;<strong>Shih, T.-L<\/strong>.; Zeng, Q.; Hofferberth, J. E. \u201dSynthesis of Stereodefined&nbsp;<em>Z<\/em>-Vinyl Iodides from Carbohydrates as a Prelude to C\/D Ring Assembly in Taxanes\u201d&nbsp;<em>Tetrahedron Lett.<\/em>&nbsp;<strong>1999<\/strong>,&nbsp;<em>40<\/em>, 3519.<\/p>\n\n\n\n<p>53. Paquette, L. A.; Wang, H.-L.; Zeng, Q.;&nbsp;<strong>Shih, T.-L<\/strong>.\u201dHeteroatomic Modulation of Oxyanionic Cope Rearrangement Rates. Consequences on Competing Nucleophilic Cleavage of an Oxetane Ring in Precursors to Paclitaxel\u201d<em>&nbsp;J. Org. Chem.<\/em>&nbsp;<strong>1998<\/strong>,&nbsp;<em>63<\/em>, 6432.<\/p>\n\n\n\n<p>54. Andrus, M. B.;&nbsp;<strong>Shih, T.-L&nbsp;<\/strong>\u201cSynthesis of Tuckolide, a New Cholesterol Biosynthesis Inhibitor\u201d&nbsp;<em>J. Org. Chem.<\/em>&nbsp;<strong>1996<\/strong>,<em>&nbsp;61<\/em>, 8780.<\/p>\n\n\n\n<p>55. Li, C.;<strong>&nbsp;Shih, T.-L.<\/strong>; Jeong, J. U.; Arasappan, A.; Fuchs, P. L. \u201dThe Use of Tetramethylguanidinium Azide in Non-halogenated Solvents Avoids Potential Explosion Hazards\u201d&nbsp;<em>Tetrahedron Lett.&nbsp;<\/em><strong>1994<\/strong>,&nbsp;<em>35<\/em>, 264.<\/p>\n\n\n\n<p>56. Wu, C.-L; Huang, C.-D.;&nbsp;<strong>Shih, T.-L<\/strong>.\u201cA Sesquiterpene Oxide of a Novel Skeleton From the Liverwort Plagiochila peculiaris\u201d&nbsp;<em>Tetrahedron Lett.<\/em>&nbsp;<strong>1993<\/strong>,<em>&nbsp;34<\/em>, 4855.<\/p>\n\n\n\n<p>57. Johnson, S. C.; Dahl, J.;&nbsp;<strong>Shih, T.-L.<\/strong>; Schedler, D. J. A.; Anderson, L.; Benjamin, T. L.; Baker, D. C.\u201cSynthesis and Evaluation of 3-Modified 1D-<em>Myo<\/em>-Inositols as Inhibitors and Substrates of Phosphatidylinositol Synthase and Inhibitors of&nbsp;<em>Myo<\/em>-Inositol Uptake by Cells\u201d&nbsp;<em>J. Med. Chem.<\/em>&nbsp;<strong>1993<\/strong>,&nbsp;<em>36<\/em>, 3628.<\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":16,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"wp-custom-template-member-empty-template","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"acf":[],"_links":{"self":[{"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/posts\/3769"}],"collection":[{"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"\/chemistry\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3769"}],"version-history":[{"count":41,"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/posts\/3769\/revisions"}],"predecessor-version":[{"id":9580,"href":"\/chemistry\/index.php?rest_route=\/wp\/v2\/posts\/3769\/revisions\/9580"}],"wp:attachment":[{"href":"\/chemistry\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3769"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/chemistry\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3769"},{"taxonomy":"post_tag","embeddable":true,"href":"\/chemistry\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3769"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}